Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20084066 | 0.87 | ALDH1A1 (0.30) | RAB9AALDH1A1HPGD | |
| SCHEMBL20084271 | 0.87 | RAB9A (0.37) | POLBCYP2C9CYP2C19RAB9AALDH1A1 | |
| SCHEMBL20084119 | 0.87 | HPGD (0.35) | POLBCYP2C9CYP2C19RAB9AALDH1A1 | |
| SCHEMBL20084029 | 0.86 | HPGD (0.34) | CYP2C9RAB9AALDH1A1HPGDNPC1 | |
| SCHEMBL20084311 | 0.80 | — | — | |
| SCHEMBL20085114 | 0.80 | RAB9A (0.39) | POLBCYP2C9CYP2C19RAB9AALDH1A1 | |
| SCHEMBL20084333 | 0.79 | RAB9A (0.39) | POLBCYP2C9CYP2C19RAB9AALDH1A1 | |
| SCHEMBL20085209 | 0.79 | HPGD (0.39) | POLBCYP2C9CYP2C19RAB9AALDH1A1 | |
| SCHEMBL20084487 | 0.78 | RAB9A (0.40) | POLBCYP2C9CYP2C19RAB9AALDH1A1 | |
| SCHEMBL21572162 | 0.78 | HPGD (0.33) | RAB9AALDH1A1HPGDNPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |