Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20084024 | 0.90 | HPGD (0.34) | HPGDNPSR1MAPTRECQLRAB9A | |
| SCHEMBL21572424 | 0.85 | MAPT (0.31) | MAPTALDH1A1 | |
| SCHEMBL20084855 | 0.82 | RAB9A (0.31) | RAB9ANPC1 | |
| SCHEMBL20085113 | 0.80 | — | — | |
| SCHEMBL18331797 | 0.80 | ALOX5 (0.35) | HPGDNPSR1MAPTALDH1A1 | |
| SCHEMBL20084762 | 0.78 | HPGD (0.35) | HPGDNPSR1MAPTRECQLRAB9A | |
| SCHEMBL20084656 | 0.78 | — | — | |
| SCHEMBL20084249 | 0.78 | POLB (0.34) | HPGDNPSR1MAPTRECQLRAB9A | |
| SCHEMBL20084768 | 0.77 | — | — | |
| SCHEMBL21970716 | 0.76 | HPGD (0.35) | HPGDNPSR1MAPTRECQLRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2019-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | SRC, GRK2, GRK3 | HPGD 4029/4885NPSR1 2136/4885MAPT 3267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.