Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000325 | 0.95 | RAB9A (0.41) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL1998393 | 0.94 | TP53 (0.47) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL2006152 | 0.93 | LMNA (0.43) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL2007846 | 0.93 | NPC1 (0.40) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL2001583 | 0.90 | LMNA (0.40) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL2004345 | 0.90 | SMPD1 (0.41) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL2002145 | 0.90 | LMNA (0.43) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL2003332 | 0.89 | SMN1; SMN2 (0.39) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL2003287 | 0.88 | LMNA (0.34) | RAB9ALMNAHPGDSMN1; SMN2NPC1 | |
| SCHEMBL2008177 | 0.87 | TP53 (0.47) | RAB9ALMNAHPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |