Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005780 | 0.95 | LMNA (0.41) | LMNAMAPK1TSHRL3MBTL1GSK3B | |
| SCHEMBL2003553 | 0.94 | GSK3B (0.42) | LMNAMAPK1TSHRL3MBTL1GSK3B | |
| SCHEMBL2004501 | 0.94 | LMNA (0.43) | LMNAMAPK1TSHRL3MBTL1GSK3B | |
| SCHEMBL2001925 | 0.93 | LMNA (0.41) | LMNAMAPK1TSHRL3MBTL1GSK3B | |
| SCHEMBL2009470 | 0.91 | S1PR1 (0.43) | LMNAMAPK1TSHRL3MBTL1GSK3B | |
| SCHEMBL2006062 | 0.91 | CYP1A2 (0.48) | LMNAMAPK1TSHRL3MBTL1GSK3B | |
| SCHEMBL2008469 | 0.90 | RAB9A (0.42) | LMNATSHRL3MBTL1GSK3BCYP3A4 | |
| SCHEMBL2005430 | 0.90 | LMNA (0.41) | LMNAMAPK1TSHRL3MBTL1GSK3B | |
| SCHEMBL1999914 | 0.88 | GSK3B (0.42) | LMNAMAPK1TSHRL3MBTL1GSK3B | |
| SCHEMBL2008018 | 0.87 | GSK3B (0.44) | LMNAMAPK1TSHRL3MBTL1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |