Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 3/20 | 0.43 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18181864 | 0.86 | HTR2A (0.49) | HTR2ASLC6A4KCNH2KMT2AMEN1 | |
| SCHEMBL16792505 | 0.84 | GCK (0.48) | HTR2ASLC6A4KCNH2KMT2AMEN1 | |
| SCHEMBL4060551 | 0.84 | PARP10 (0.47) | HTR2ASLC6A4KCNH2KMT2AMEN1 | |
| SCHEMBL30764801 | 0.84 | GCK (0.48) | HTR2ASLC6A4KCNH2KMT2AMEN1 | |
| SCHEMBL18181867 | 0.84 | AR (0.50) | HTR2ASLC6A4KCNH2KMT2APARP10 | |
| SCHEMBL12259261 | 0.82 | HTR2A (0.60) | HTR2ASLC6A4KCNH2KMT2AMEN1 | |
| SCHEMBL16792734 | 0.80 | PARP10 (0.44) | HTR2ASLC6A4KCNH2KMT2AMEN1 | |
| SCHEMBL20085191 | 0.80 | ALDH1A1 (0.46) | HTR2ASLC6A4KMT2AMEN1LMNA | |
| SCHEMBL6293051 | 0.80 | PARP10 (0.66) | SLC6A4KMT2AMEN1LMNAHTT | |
| SCHEMBL20084440 | 0.79 | HTR2A (0.43) | HTR2ASLC6A4KCNH2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| EP-3492461-A1 | NITROGENOUS HETEROCYCLIC AROMATIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION THEREOF | Shanghai Yingli Pharmaceutical Co. Ltd. (CN) | 2019-06-05 | — | — | EP | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |