Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGAV | P06756 | 2/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17262997 | 0.90 | ADRB3 (0.38) | ADRB3NR3C1KCNK3KMT2AMEN1 | |
| SCHEMBL13719466 | 0.90 | ADRB3 (0.38) | ADRB3NR3C1KCNK3KMT2AMEN1 | |
| SCHEMBL15914068 | 0.80 | NR3C1 (0.34) | ADRB3NR3C1KMT2AMEN1CHRNA7 | |
| SCHEMBL15914067 | 0.80 | NR3C1 (0.34) | ADRB3NR3C1KMT2AMEN1CHRNA7 | |
| SCHEMBL7018373 | 0.77 | NNMT (0.42) | NR3C1KCNK3KMT2AMEN1CHRNA7 | |
| SCHEMBL13829314 | 0.77 | NNMT (0.42) | NR3C1KCNK3KMT2AMEN1CHRNA7 | |
| SCHEMBL20139059 | 0.76 | KCNK3 (0.43) | ADRB3KCNK3KMT2AMEN1CHRNA7 | |
| SCHEMBL7015928 | 0.74 | ITGB1 (0.46) | ADRB3KCNK3KMT2AMEN1CHRNA7 | |
| SCHEMBL7015933 | 0.74 | ITGB1 (0.46) | ADRB3KCNK3KMT2AMEN1CHRNA7 | |
| SCHEMBL18031589 | 0.72 | SMN1; SMN2 (0.41) | KMT2AMEN1KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180110762-A1 | Compositions Methods for Treating Chronic Kidney Disease | MERCK SHARP & DOHME CORP (US) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180110762-A1 | Compositions Methods for Treating Chronic Kidney Disease | ITGAM, ITGAL, ITGB1 | ADRB3 938/4885NR3C1 1071/4885KCNK3 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.