Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20087369 | 0.90 | ALDH1A1 (0.31) | ALDH1A1CYP1A2HPGDCYP2C19BLM | |
| SCHEMBL20087354 | 0.89 | ALDH1A1 (0.32) | ALDH1A1CYP1A2HPGDCYP2C19BLM | |
| SCHEMBL20087359 | 0.84 | MGLL (0.37) | ALDH1A1CYP1A2HPGDCYP2C19BLM | |
| SCHEMBL20087402 | 0.82 | ALDH1A1 (0.36) | ALDH1A1CYP1A2HPGDCYP2C19BLM | |
| SCHEMBL23910542 | 0.82 | MGLL (0.34) | ALDH1A1CYP1A2HPGDCYP2C19BLM | |
| SCHEMBL20091613 | 0.82 | ALDH1A1 (0.37) | ALDH1A1CYP1A2HPGDCYP2C19BLM | |
| SCHEMBL20968650 | 0.79 | — | — | |
| SCHEMBL20087394 | 0.79 | AKT1 (0.36) | ALDH1A1CYP1A2HPGDCYP2C19BLM | |
| SCHEMBL20087398 | 0.78 | ALDH1A1 (0.31) | ALDH1A1CYP1A2HPGDCYP2C19BLM | |
| SCHEMBL20087393 | 0.77 | PTGS1 (0.42) | ALDH1A1CYP1A2HPGDCYP2C19BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912982-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | Hangzhou Dac Biotech Co., Ltd (CN) | 2021-11-24 | — | — | EP | disclosed |
| EP-3271329-B1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | HANGZHOU DAC BIOTECH CO LTD (CN) | 2021-08-18 | — | — | EP | disclosed |
| US-10456479-B2 | Hydrophilic linkers and ligand-drug conjugates thereof | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2019-10-29 | — | — | US | disclosed |
| US-20180110876-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2018-04-26 | — | — | US | disclosed |
| US-20180110876-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10456479-B2 | Hydrophilic linkers and ligand-drug conjugates thereof | CD44, SELPLG, EPCAM | ALDH1A1 1069/4885CYP1A2 2537/4885HPGD 1325/4885 |
| US-20180110876-A1 | NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF | CD44, HACD3, HACD2 | ALDH1A1 1285/4885CYP1A2 3109/4885HPGD 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.