SCHEMBL20087474

SCHEMBL20087474

c1ccc([Si]2(c3ccccc3)c3ccccc3-c3ccccc3-c3ccccc32)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
CES2 O00748 1/20 0.33
APAF1 O14727 1/20 0.33
TERT O14746 1/20 0.33
NPC1 O15118 1/20 0.33
PLIN1 O60240 1/20 0.33
TDP2 O95551 1/20 0.33
S1PR4 O95977 1/20 0.33
LMNA P02545 1/20 0.33
PLA2G1B P04054 1/20 0.33
BCHE P06276 1/20 0.33
POLB P06746 1/20 0.33
PTPRC P08575 1/20 0.33
MAPT P10636 1/20 0.33
THRB P10828 1/20 0.33
PLCG1 P19174 1/20 0.33
MAOA P21397 1/20 0.33
S1PR1 P21453 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6255341 0.97 MEN1 (0.30) MEN1THRBKMT2A
SCHEMBL31424212 0.97 MEN1 (0.30) MEN1THRBKMT2A
SCHEMBL25643746 0.95 THRB (0.33) THRB
SCHEMBL31040329 0.84 ALDH1A1 (0.40) MAPK1MEN1NPC1PTPRCMAPT
SCHEMBL20138901 0.84 ALDH1A1 (0.40) MAPK1MEN1NPC1PTPRCMAPT
SCHEMBL17993953 0.84 APP (0.31)
SCHEMBL23039731 0.83 MEN1 (0.48) MAPK1KDM4EMEN1CES2APAF1
SCHEMBL24120875 0.83 MEN1 (0.40) MAPK1KDM4EMEN1CES2APAF1
SCHEMBL9604056 0.83 CALM1 (0.35) LMNAALDH1A1TSHRHSD17B10
SCHEMBL24120853 0.83 MEN1 (0.40) MAPK1KDM4EMEN1CES2APAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10236458-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2019-03-19 US disclosed
US-20180114929-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION 2018-04-26 US disclosed
US-20180114929-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION 2018-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10236458-B2 Organic electroluminescent materials and devices OCIAD2, OCIAD1, OPA1 MAPK1 3722/4885KDM4E 3642/4885MEN1 3809/4885
US-20180114929-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, OPA1 MAPK1 3722/4885KDM4E 3642/4885MEN1 3809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.