Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23195341 | 0.88 | PSIP1 (0.52) | PSIP1HSD11B1TDP1SMN1; SMN2HTR6 | |
| SCHEMBL22952850 | 0.82 | TDP1 (0.42) | TDP1SMN1; SMN2ALDH1A1NPSR1CYP2C19 | |
| SCHEMBL18852692 | 0.81 | PSIP1 (0.48) | PSIP1HSD11B1TDP1SMN1; SMN2HTR6 | |
| SCHEMBL25062242 | 0.80 | TDP1 (0.46) | PSIP1HSD11B1TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21364029 | 0.78 | CA1 (0.44) | HSD11B1SMN1; SMN2ALDH1A1MMP1MMP2 | |
| SCHEMBL13703524 | 0.76 | PSIP1 (0.52) | PSIP1HSD11B1TDP1SMN1; SMN2HTR6 | |
| SCHEMBL24160936 | 0.76 | LMNA (0.44) | TDP1ALDH1A1TSHR | |
| SCHEMBL6053419 | 0.76 | PSIP1 (0.47) | PSIP1HSD11B1TDP1SMN1; SMN2HTR6 | |
| SCHEMBL28138720 | 0.75 | HSD11B1 (0.45) | PSIP1HSD11B1TDP1ALDH1A1CYP2C19 | |
| SCHEMBL19335680 | 0.75 | CA1 (0.46) | HTR6ALDH1A1CYP2C19HSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075699-A1 | OXYSTEROLS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2018-04-26 | — | — | WO | disclosed |