Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VRK1 | Q99986 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20089643 | 0.82 | CYP2A6 (0.34) | — | |
| SCHEMBL20115965 | 0.81 | ALOX5AP (0.30) | ALOX5APPDE2A | |
| SCHEMBL12169540 | 0.80 | ALOX5AP (0.40) | VRK1ALOX5AP | |
| SCHEMBL26329520 | 0.77 | PIK3CA (0.35) | VRK1ALOX5APPDE2A | |
| SCHEMBL7940202 | 0.76 | AGBL2 (0.43) | VRK1PDE2A | |
| SCHEMBL20095651 | 0.76 | PDE2A (0.33) | ALOX5APPDE2A | |
| SCHEMBL18649026 | 0.76 | RIPK1 (0.40) | PDE2A | |
| SCHEMBL19497736 | 0.76 | HDAC1 (0.33) | PDE2A | |
| SCHEMBL19833099 | 0.74 | ESR1 (0.31) | PDE2A | |
| SCHEMBL26340897 | 0.73 | VRK1 (0.37) | VRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180111931-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA PHARMACEUTICALS LP | 2018-04-26 | — | — | US | disclosed |
| US-20180111931-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA PHARMACEUTICALS LP | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111931-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | VRK1 3618/4885ALOX5AP 2336/4885PDE2A 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.