⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20086553 | 0.81 | LMNA (0.31) | — | |
| SCHEMBL20091022 | 0.79 | NFE2L2 (0.46) | — | |
| SCHEMBL20091101 | 0.75 | TYMP (0.32) | — | |
| SCHEMBL20090993 | 0.71 | LMNA (0.30) | — | |
| SCHEMBL18215464 | 0.70 | — | — | |
| SCHEMBL23640096 | 0.69 | RAB9A (0.54) | — | |
| SCHEMBL489023 | 0.67 | MEN1 (0.50) | — | |
| SCHEMBL16874337 | 0.67 | MEN1 (0.50) | — | |
| SCHEMBL23457284 | 0.67 | — | — | |
| SCHEMBL20090979 | 0.67 | NFE2L2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10421751-B2 | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | LYCERA CORPORATION (US) | 2019-09-24 | — | — | US | disclosed |
| US-20180111922-A1 | DIHYDRO-2H-BENZO[b][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATEMENT OF DISEASE | LYCERA CORPORATION | 2018-04-26 | — | — | US | disclosed |