Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 9/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 3/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL129817 | 0.85 | CHUK (0.44) | CDK2PDPK1GDACHUKCDK1 | |
| SCHEMBL8485064 | 0.83 | PDPK1 (0.36) | CDK2PDPK1GDACHUKCDK1 | |
| SCHEMBL2938904 | 0.81 | BRAF (0.36) | CDK2PDPK1GDACHUKCDK1 | |
| SCHEMBL887882 | 0.77 | BRAF (0.39) | CDK2PDPK1GDACHUKCDK1 | |
| SCHEMBL8348019 | 0.77 | NLRP3 (0.40) | CDK2CHUKCDK1BRAFPRKACA | |
| SCHEMBL9168808 | 0.77 | APP (0.44) | CDK2PDPK1GDACHUKCDK1 | |
| Guanine SCHEMBL2216795 | 0.77 | BRAF (0.38) | CDK2PDPK1GDACDK1BRAF | |
| SCHEMBL135689 | 0.77 | CDK2 (0.52) | CDK2PDPK1GDACDK1DPP4 | |
| Guanine SCHEMBL31714144 | 0.77 | BRAF (0.38) | CDK2PDPK1GDACDK1BRAF | |
| 2,6-Diaminopurine SCHEMBL24052 | 0.76 | GDA (0.48) | CDK2PDPK1GDACDK1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2019-06-18 | — | — | US | disclosed |
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS AG (CH) | 2019-04-11 | — | — | US | disclosed |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190105324-A9 | SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKAR2B | CDK2 210/4885PDPK1 19/4885GDA 2485/4885 |
| US-20180110783-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | CDK2 212/4885PDPK1 9/4885GDA 2744/4885 |
| US-10322130-B2 | Substituted chromenones as modulators of protein kinases | MAP3K1, CSNK1A1, MAP3K2 | CDK2 48/4885PDPK1 50/4885GDA 4179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.