Sugi Predict

Sugi Predict / Compounds / SCHEMBL20093434

SCHEMBL20093434

SCHEMBL20093434

Cc1noc(C)c1-c1n[nH]c2ncnc(N)c12

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 8/20 0.43
▸ JAK2 O60674 1/20 0.43
▸ CYP1A2 P05177 8/20 0.40
▸ ALDH1A1 P00352 4/20 0.40
▸ TSHR P16473 2/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ CLK4 Q9HAZ1 2/20 0.40
▸ HIF1A Q16665 1/20 0.40
▸ CYP3A4 P08684 3/20 0.37
▸ ALOX15 P16050 3/20 0.37
▸ HSD17B10 Q99714 3/20 0.37
▸ CYP2C19 P33261 3/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ CYP2C9 P11712 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19414294 0.73 BRD4 (0.33) BRD4CYP1A2ALDH1A1TSHRMEN1
SCHEMBL1598752 0.72 PIK3CD (0.44) MEN1KMT2A
SCHEMBL130603 0.72 RET (0.56) CYP1A2
SCHEMBL3782102 0.70 PIK3CD (0.57) CYP1A2ALDH1A1TSHRMEN1KMT2A
SCHEMBL20793900 0.70 JAK2 (0.42) JAK2MEN1KMT2ALMNA
SCHEMBL20093453 0.69 PIK3CD (0.46) MEN1KMT2A
SCHEMBL18518420 0.69 RET (0.64) CYP1A2
SCHEMBL21048476 0.68 PIK3CG (0.59) CYP1A2CLK4ALOX15HSD17B10CYP2C19
SCHEMBL18493858 0.68 RET (0.50) CYP1A2MEN1KMT2ACYP2C19CYP2D6
SCHEMBL30990496 0.67 RET (0.53) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210401840-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2021-12-30 — — US disclosed
US-10322130-B2 Substituted chromenones as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2019-06-18 — — US disclosed
US-20190105324-A9 SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2019-04-11 — — US disclosed
US-20180110783-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS SA (CH) 2018-04-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210401840-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB BRD4 816/4885JAK2 290/4885CYP1A2 4618/4885
US-20190105324-A9 SUBSTITUTED CHROMENONES AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKAR2B BRD4 1142/4885JAK2 355/4885CYP1A2 3432/4885
US-20180110783-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB BRD4 816/4885JAK2 290/4885CYP1A2 4618/4885
US-10322130-B2 Substituted chromenones as modulators of protein kinases MAP3K1, CSNK1A1, MAP3K2 BRD4 2420/4885JAK2 360/4885CYP1A2 664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.