Sugi Predict

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SCHEMBL130603

SCHEMBL130603

Cc1noc(C)c1-c1nn(C)c2ncnc(N)c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 5/20 0.56
▸ PIK3CD O00329 12/20 0.52
▸ PIK3CA P42336 12/20 0.52
▸ PIK3CB P42338 12/20 0.52
▸ PIK3CG P48736 12/20 0.52
▸ PRKDC P78527 12/20 0.52
▸ HCK P08631 10/20 0.52
▸ ABL1 P00519 9/20 0.52
▸ EGFR P00533 9/20 0.52
▸ SRC P12931 9/20 0.52
▸ MTOR P42345 9/20 0.52
▸ EPHB4 P54760 9/20 0.52
▸ KDR P35968 9/20 0.52
▸ PI4KB Q9UBF8 2/20 0.52
▸ NUDT14 O95848 1/20 0.46
▸ NUDT5 Q9UKK9 1/20 0.46
▸ SIGMAR1 Q99720 1/20 0.41
▸ AURKA O14965 1/20 0.40
▸ IKBKE Q14164 1/20 0.40
▸ AURKB Q96GD4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL130631 0.76 PIK3CD (0.49) RETPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL10260251 0.76 PIK3CD (0.52) RETPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL130503 0.74 PIK3CD (0.60) RETPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL4226449 0.73 SIGMAR1 (0.41) PIK3CAMTORSIGMAR1CYP1A2
SCHEMBL130502 0.73 PIK3CD (0.60) RETPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL130618 0.73 PIK3CD (0.68) RETPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL20093434 0.72 BRD4 (0.43) CYP1A2
SCHEMBL13828427 0.72 RET (0.39) RETPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL17970654 0.72 PIK3CD (0.46) RETPIK3CDPIK3CAPIK3CBPIK3CG
SCHEMBL18518591 0.72 RET (1.00) RETHCKKDRCYP1A2FGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 — — US disclosed
US-11858907-B2 Kinase modulators RHIZEN PHARMACEUTICALS AG (CH) 2024-01-02 — — US disclosed
US-20200239427-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2020-07-30 — — US disclosed
US-10442783-B2 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2019-10-15 — — US disclosed
US-10220035-B2 Compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2019-03-05 — — US disclosed
US-20180110783-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS SA (CH) 2018-04-26 — — US disclosed
US-20160318890-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2016-11-03 — — US disclosed
US-9421209-B2 Kinase modulators RHIZEN PHARMACEUTICALS SA (CH) 2016-08-23 — — US disclosed
US-20150320752-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2015-11-12 — — US disclosed
US-20150174131-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS AG (CH) 2015-06-25 — — US disclosed
US-9018375-B2 Substituted chromenes as kinase modulators RHIZEN PHARMACEUTICALS SA (CH) 2015-04-28 — — US disclosed
US-20140080827-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS SA (CH) 2014-03-20 — — US disclosed
US-8642607-B2 4H-chromen-4-one compounds as modulators of protein kinases RHIZEN PHARMACEUTICALS SA (CH) 2014-02-04 — — US disclosed
US-20120289496-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES RHIZEN PHARMACEUTICALS SA (CH) 2012-11-15 — — US disclosed
US-20120059001-A1 NOVEL KINASE MODULATORS INCOZEN THERAPEUTICS PVT. LTD. (IN) 2012-03-08 — — US disclosed
US-20110118257-A1 NOVEL KINASE MODULATORS RHIZEN PHARMACEUTICALS SA (CH) 2011-05-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10442783-B2 2,3-disubstituted chromen-4-one compounds as modulators of protein kinases PIK3CB, PIK3CD, PDPK1 RET 655/4885PIK3CD 2/4885PIK3CA 4/4885
US-20150174131-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB RET 1007/4885PIK3CD 70/4885PIK3CA 143/4885
US-20150320752-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB RET 733/4885PIK3CD 47/4885PIK3CA 88/4885
US-20120289496-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB RET 733/4885PIK3CD 47/4885PIK3CA 88/4885
US-10220035-B2 Compounds as modulators of protein kinases PRKCA, PRKCH, PRKCE RET 693/4885PIK3CD 30/4885PIK3CA 64/4885
US-20180110783-A1 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES PRKCA, PRKCH, PRKCB RET 733/4885PIK3CD 47/4885PIK3CA 88/4885
US-20140080827-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB RET 1007/4885PIK3CD 70/4885PIK3CA 143/4885
US-20110118257-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB RET 1007/4885PIK3CD 70/4885PIK3CA 143/4885
US-20200239427-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB RET 1007/4885PIK3CD 70/4885PIK3CA 143/4885
US-11858907-B2 Kinase modulators RPS6KA1, RPS6KA2, PRKAR2A RET 484/4885PIK3CD 103/4885PIK3CA 144/4885
US-20160318890-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB RET 1007/4885PIK3CD 70/4885PIK3CA 143/4885
US-20120059001-A1 NOVEL KINASE MODULATORS PRKCA, PRKCH, PRKCB RET 1007/4885PIK3CD 70/4885PIK3CA 143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.