Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 11/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.64 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.63 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.63 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.63 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19227480 | 0.90 | HSD11B1 (0.64) | L3MBTL3L3MBTL1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL21611002 | 0.89 | L3MBTL3 (0.62) | L3MBTL3L3MBTL1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL24042650 | 0.88 | L3MBTL3 (0.62) | L3MBTL3L3MBTL1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL21610999 | 0.88 | L3MBTL3 (0.60) | L3MBTL3L3MBTL1HSD11B1KDM4EALDH1A1 | |
| SCHEMBL17689118 | 0.87 | HPGD (0.66) | L3MBTL1HSD11B1ALDH1A1 | |
| SCHEMBL1912013 | 0.85 | LRRK2 (0.69) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL17689086 | 0.85 | HPGD (0.64) | L3MBTL1HSD11B1ALDH1A1 | |
| SCHEMBL21475151 | 0.84 | L3MBTL3 (0.60) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL13090086 | 0.83 | ALDH1A1 (0.69) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL23997109 | 0.82 | L3MBTL3 (0.59) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075608-A1 | PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DCLK1/2-MEDIATED DISORDERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-26 | — | — | WO | disclosed |