Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437263 | 0.76 | LMNA (0.51) | LMNAMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL27574887 | 0.74 | SIRT1 (0.51) | SIRT1SIRT2MEN1ALDH1A1MAPT | |
| SCHEMBL14068343 | 0.73 | LMNA (0.49) | LMNAMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL29956275 | 0.73 | LMNA (0.57) | LMNAADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL27531831 | 0.71 | SIRT1 (0.50) | SIRT1SIRT2MEN1ALDH1A1MAPT | |
| SCHEMBL21731624 | 0.71 | HTR2A (0.47) | LMNAADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL5793847 | 0.70 | HTR2A (0.65) | LMNAADRA2AADRA2BADRA2CHTR7 | |
| SCHEMBL10740843 | 0.69 | TDP1 (0.35) | AHR | |
| SCHEMBL10745098 | 0.69 | TDP1 (0.35) | AHR | |
| SCHEMBL10745606 | 0.69 | TP53 (0.37) | LMNAADRA2AADRA2BADRA2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339189-B2 | DNA primase and gyrase inhibitors | B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY (IL) | 2022-05-24 | — | — | US | disclosed |
| US-20190248836-A1 | DNA PRIMASE AND GYRASE INHIBITORS | B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY (IL) | 2019-08-15 | — | — | US | disclosed |
| WO-2018073828-A1 | DNA PRIMASE AND GYRASE INHIBITORS | B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY (IL) | 2018-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248836-A1 | DNA PRIMASE AND GYRASE INHIBITORS | TOP2A, TOP1, DNA2 | LMNA 741/4885ADRA2A 4786/4885ADRA2B 4764/4885 |
| US-11339189-B2 | DNA primase and gyrase inhibitors | TOP2A, TOP1, DNA2 | LMNA 741/4885ADRA2A 4786/4885ADRA2B 4764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.