Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20094779 | 0.81 | KMT2A (0.45) | KMT2AALDH1A1KDM4EGLADAO | |
| SCHEMBL14269441 | 0.71 | DAO (0.44) | KMT2AALDH1A1KDM4EDAOMEN1 | |
| SCHEMBL21282678 | 0.70 | KMT2A (0.46) | KMT2AALDH1A1KDM4EGLAMEN1 | |
| SCHEMBL20094572 | 0.70 | GAA (0.40) | ALDH1A1DAOSMN1; SMN2LMNARAB9A | |
| SCHEMBL1948876 | 0.66 | KMT2A (0.67) | KMT2AALDH1A1KDM4EGLAMEN1 | |
| SCHEMBL20094767 | 0.64 | DAO (0.49) | ALDH1A1KDM4EDAOMAPTLMNA | |
| SCHEMBL2608298 | 0.64 | — | — | |
| SCHEMBL15318227 | 0.63 | HSD17B10 (0.45) | KMT2AALDH1A1DAOMEN1MAPT | |
| SCHEMBL9019670 | 0.62 | KMT2A (0.56) | KMT2AALDH1A1KDM4EGLAMEN1 | |
| SCHEMBL18880072 | 0.62 | ALDH1A1 (0.73) | KMT2AALDH1A1KDM4EGLAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075842-A1 | CONDENSED BENZODIAZEPINE DERIVATIVES AND CONJUGATES MADE THEREFROM | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-26 | — | — | WO | disclosed |