Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 5/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20094517 | 0.88 | MAPT (0.49) | DAOBRD4ALOX15POLBMAPT | |
| SCHEMBL15318227 | 0.78 | HSD17B10 (0.45) | DAOBRD4POLBRAB9ALMNA | |
| SCHEMBL20094572 | 0.77 | GAA (0.40) | DAOSMYD3ALOX15RAB9ALMNA | |
| SCHEMBL20094573 | 0.76 | MMP13 (0.56) | ALOX15POLBRAB9ALMNAMAPT | |
| SCHEMBL13753894 | 0.76 | BRD4 (0.44) | DAOBRD4ALOX15RAB9ALMNA | |
| SCHEMBL163704 | 0.76 | BRD4 (0.44) | DAOBRD4ALOX15POLBALDH1A1 | |
| SCHEMBL15318252 | 0.75 | BAZ2B (0.50) | RAB9ALMNAALDH1A1KDM4EGAA | |
| SCHEMBL21180765 | 0.72 | ALDH1A1 (0.42) | BRD4ALOX15RAB9ALMNAALDH1A1 | |
| SCHEMBL12368426 | 0.69 | ALDH1A1 (0.65) | BRD4POLBLMNAMAPTALDH1A1 | |
| SCHEMBL25782683 | 0.68 | ALOX15 (0.44) | ALOX15POLBLMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075842-A1 | CONDENSED BENZODIAZEPINE DERIVATIVES AND CONJUGATES MADE THEREFROM | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-26 | — | — | WO | disclosed |