Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095509 | 0.88 | HTR2C (0.33) | HTR2CSCN9A | |
| SCHEMBL20095495 | 0.85 | HTR2C (0.39) | HTR2CSCN9AHTR2AHTR2BHRH3 | |
| SCHEMBL20095503 | 0.83 | SCN9A (0.43) | HTR2CSCN9A | |
| SCHEMBL20095510 | 0.81 | HTR2C (0.44) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL20096083 | 0.81 | AKR1C3 (0.37) | — | |
| SCHEMBL20095506 | 0.80 | HTR2C (0.42) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL21296536 | 0.79 | HTR2C (0.49) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL20063858 | 0.79 | HTR2C (0.49) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL20063859 | 0.79 | HTR2C (0.49) | HTR2CSCN9ADRD2HTR2AHTR2B | |
| SCHEMBL20063931 | 0.79 | HTR2C (0.49) | HTR2CSCN9ADRD2HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |