Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095906 | 0.85 | HTR2C (0.44) | HTR2CHTR2AHTR2BHRH3SCN9A | |
| SCHEMBL20096083 | 0.82 | AKR1C3 (0.37) | — | |
| SCHEMBL20095509 | 0.79 | HTR2C (0.33) | HTR2CSCN9A | |
| SCHEMBL20072886 | 0.77 | HTR2C (0.44) | HTR2CHTR2AHTR2BHRH3SCN9A | |
| SCHEMBL20095503 | 0.76 | SCN9A (0.43) | HTR2CSCN9A | |
| SCHEMBL20073072 | 0.72 | SCN9A (0.43) | HTR2CHTR2AHTR2BHRH3SCN9A | |
| SCHEMBL20063481 | 0.72 | SCN9A (0.43) | HTR2CHTR2AHTR2BHRH3SCN9A | |
| SCHEMBL20095962 | 0.70 | HTR2C (0.49) | HTR2CHTR2AHTR2BHRH3PROKR1 | |
| SCHEMBL20095682 | 0.70 | HTR2C (0.49) | HTR2CHTR2AHTR2BHRH3PROKR1 | |
| SCHEMBL20095685 | 0.70 | HTR2C (0.49) | HTR2CHTR2AHTR2BHRH3PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |