Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095509 | 0.85 | HTR2C (0.33) | SCN9AHCRTR2HTR2C | |
| SCHEMBL20095906 | 0.83 | HTR2C (0.44) | SCN9AHTR2C | |
| SCHEMBL23140809 | 0.81 | SCN9A (0.48) | SCN9AHCRTR2FFAR1HTR2CCETP | |
| SCHEMBL20096083 | 0.78 | AKR1C3 (0.37) | — | |
| SCHEMBL23638947 | 0.78 | SCN9A (0.48) | SCN9AHCRTR2FFAR1CETPMGLL | |
| SCHEMBL20063488 | 0.77 | SCN9A (0.53) | SCN9AHCRTR2 | |
| SCHEMBL23638940 | 0.76 | SCN9A (0.51) | SCN9AHCRTR2FFAR1TAS1R3TAS1R1 | |
| SCHEMBL20095502 | 0.76 | DRD2 (0.42) | SCN9A | |
| SCHEMBL20095495 | 0.76 | HTR2C (0.39) | SCN9AHTR2C | |
| SCHEMBL20096086 | 0.74 | SCN9A (0.42) | SCN9AHCRTR2FFAR1HTR2CCETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |