Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 4/20 | 0.33 |
| ▸ | HTR7 | P34969 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20810121 | 0.75 | CCR2 (0.30) | — | |
| SCHEMBL13660349 | 0.75 | CCR2 (0.30) | — | |
| SCHEMBL13985486 | 0.73 | LMNA (0.41) | — | |
| SCHEMBL12186297 | 0.72 | — | — | |
| SCHEMBL4325170 | 0.72 | LMNA (0.44) | SLC6A4DRD2DRD1SLC6A2SLC6A3 | |
| SCHEMBL30583131 | 0.72 | LMNA (0.44) | SLC6A4DRD2DRD1SLC6A2SLC6A3 | |
| SCHEMBL17181427 | 0.71 | — | — | |
| SCHEMBL24424915 | 0.71 | SLC6A2 (0.41) | SLC6A4DRD2SLC6A2SLC6A3DRD4 | |
| SCHEMBL16660719 | 0.71 | — | — | |
| SCHEMBL17306164 | 0.69 | SLC6A4 (0.42) | SLC6A4DRD2DRD1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |