Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24783009 | 0.78 | LMNA (0.40) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL20810121 | 0.77 | CCR2 (0.30) | — | |
| SCHEMBL5698477 | 0.77 | LMNA (0.42) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL13660349 | 0.77 | CCR2 (0.30) | — | |
| SCHEMBL12186297 | 0.74 | — | — | |
| SCHEMBL31545085 | 0.74 | LMNA (0.70) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL20095927 | 0.73 | SLC6A4 (0.38) | — | |
| SCHEMBL9706627 | 0.72 | LMNA (0.47) | LMNACES2ALDH1A1MEN1CYP3A4 | |
| SCHEMBL13782375 | 0.72 | LMNA (0.42) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL6435607 | 0.72 | LMNA (0.42) | LMNACES2ALDH1A1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |