Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17713325 | 0.81 | PYCR1 (0.41) | HTTLMNAPYCR1HPGDNPC1 | |
| SCHEMBL8173928 | 0.81 | LMNA (0.43) | HTTLMNAPYCR1HPGDNPC1 | |
| SCHEMBL248224 | 0.81 | IDO1 (0.50) | HTTHPGDTP53ALDH1A1IDO1 | |
| SCHEMBL30271268 | 0.81 | IDO1 (0.50) | HTTHPGDTP53ALDH1A1IDO1 | |
| SCHEMBL27519718 | 0.76 | PYCR1 (0.45) | HTTLMNAPYCR1NPC1RAB9A | |
| SCHEMBL20801052 | 0.75 | HPGD (0.38) | HTTLMNAPYCR1HPGDNPC1 | |
| SCHEMBL1569794 | 0.75 | TAAR1 (0.52) | PYCR1HTR2AHRH1 | |
| SCHEMBL32689207 | 0.75 | TAAR1 (0.52) | PYCR1HTR2AHRH1 | |
| SCHEMBL11452260 | 0.75 | PYCR1 (0.51) | PYCR1HPGDHTR2ASLC6A4ALDH1A1 | |
| SCHEMBL589200 | 0.75 | PYCR1 (0.44) | HTTLMNAPYCR1SMN1; SMN2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |