Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033196 | 0.78 | TRPV4 (0.39) | CYP11B1CYP11B2TRPV4ESR1ESR2 | |
| SCHEMBL405549 | 0.78 | TRPV4 (0.39) | CYP11B1CYP11B2TRPV4ESR1ESR2 | |
| SCHEMBL2651893 | 0.78 | TRPV4 (0.39) | CYP11B1CYP11B2TRPV4MAOBESR1 | |
| SCHEMBL8062622 | 0.77 | KDM1A (0.39) | TSHRALDH1A1 | |
| SCHEMBL17185578 | 0.75 | DHODH (0.35) | CYP11B1CYP11B2TRPV4MAOBMAOA | |
| SCHEMBL14744326 | 0.75 | KHK (0.39) | CYP11B1CYP11B2TRPV4ESR1ESR2 | |
| SCHEMBL404723 | 0.75 | ADRB2 (0.45) | CYP11B1CYP11B2TRPV4ARDHODH | |
| SCHEMBL13855817 | 0.75 | SELL (0.41) | CYP11B1CYP11B2TRPV4ESR1ESR2 | |
| SCHEMBL22119927 | 0.75 | KHK (0.39) | CYP11B1CYP11B2TRPV4MAOBESR1 | |
| SCHEMBL29490392 | 0.75 | DHODH (0.35) | CYP11B1CYP11B2TRPV4MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075871-A1 | NOVEL ANTIBIOTICS AND METHODS OF USING SAME | THE BROAD INSTITUTE, INC. (US) | 2018-04-26 | — | — | WO | disclosed |