SCHEMBL20096072

SCHEMBL20096072

CC(C)(C)OC(=O)NCc1ccc(Br)c(C#N)c1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
NSD2 O96028 1/20 0.44
CTSS P25774 4/20 0.44
CTSK P43235 4/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
AAK1 Q2M2I8 2/20 0.43
NAMPT P43490 2/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CTSB P07858 1/20 0.41
GAA P10253 1/20 0.41
KDM4A O75164 1/20 0.41
HDAC1 Q13547 1/20 0.40
FPR3 P25089 1/20 0.40
FPR2 P25090 1/20 0.40
GRM2 Q14416 1/20 0.40
GLS O94925 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3396307 0.90 NSD2 (0.46) NSD2CTSSCTSKL3MBTL1AAK1
SCHEMBL31431170 0.85 NSD2 (0.44) NSD2CTSSCTSKL3MBTL1NAMPT
SCHEMBL21241667 0.85 NSD2 (0.44) NSD2CTSSCTSKL3MBTL1NAMPT
SCHEMBL20095414 0.84 NSD2 (0.43) NSD2CTSSCTSKL3MBTL1NAMPT
SCHEMBL22829000 0.83 NSD2 (0.47) NSD2CTSSCTSKL3MBTL1AAK1
SCHEMBL6928939 0.82 TRPA1 (0.54) NSD2CTSSCTSKL3MBTL1NAMPT
SCHEMBL8011913 0.82 NSD2 (0.46) NSD2CTSSCTSKL3MBTL1AAK1
SCHEMBL8249388 0.81 HDAC1 (0.48) L3MBTL1NAMPTCA1CA2GAA
SCHEMBL850268 0.81 MEN1 (0.47) L3MBTL1NAMPTCA1CA2GAA
SCHEMBL22828999 0.81 ALDH1A1 (0.48) NSD2L3MBTL1AAK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021004467-A1 COMPOUND AS PORCUPINE INHIBITOR AND USE THEREOF 南京明德新药研发有限公司 2021-01-14 WO disclosed
WO-2018075871-A1 NOVEL ANTIBIOTICS AND METHODS OF USING SAME THE BROAD INSTITUTE, INC. (US) 2018-04-26 WO disclosed