Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6116336 | 0.79 | CYP2C9 (0.35) | MEN1KMT2AGAACTSKCTSS | |
| SCHEMBL30903258 | 0.75 | MEN1 (0.45) | MEN1KMT2AGAACTSKCTSS | |
| SCHEMBL1726115 | 0.73 | TDP1 (0.44) | MEN1KMT2AGAACTSKCTSS | |
| SCHEMBL25408315 | 0.72 | MEN1 (0.50) | MEN1KMT2AGAACTSKCTSS | |
| SCHEMBL18272943 | 0.72 | TDP1 (0.47) | MEN1KMT2AGAATDP1APLNR | |
| SCHEMBL17574265 | 0.72 | TDP1 (0.50) | MEN1KMT2AGAACTSKCTSS | |
| SCHEMBL6117334 | 0.72 | ALDH1A1 (0.40) | GAACA1CA2ALDH1A1TSHR | |
| SCHEMBL5352030 | 0.69 | MEN1 (0.46) | MEN1KMT2AGAACTSKCTSS | |
| SCHEMBL12880606 | 0.69 | MEN1 (0.46) | MEN1KMT2AGAACTSKCTSS | |
| SCHEMBL2369074 | 0.69 | MEN1 (0.46) | MEN1KMT2AGAACTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |