Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004901 | 0.93 | MAPT (0.36) | FAAHMEN1KMT2AMAPTKDM4E | |
| SCHEMBL2007905 | 0.92 | FAAH (0.37) | FAAHMEN1HTTKMT2AMAPT | |
| SCHEMBL2006664 | 0.90 | ALOX5AP (0.36) | FAAHMEN1HTTKMT2AMAPT | |
| SCHEMBL2007874 | 0.89 | FAAH (0.41) | FAAHMEN1HTTKMT2AMAPT | |
| SCHEMBL2001464 | 0.89 | MEN1 (0.44) | FAAHMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2006280 | 0.89 | FAAH (0.44) | FAAHMEN1HTTKMT2AMAPT | |
| SCHEMBL2001978 | 0.88 | FAAH (0.45) | FAAHMEN1HTTKMT2AMAPT | |
| SCHEMBL2005411 | 0.88 | ALOX5AP (0.42) | MEN1KMT2AMAPTALDH1A1ALOX5 | |
| SCHEMBL2004673 | 0.88 | ALDH1A1 (0.39) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL2002818 | 0.88 | FAAH (0.44) | FAAHMEN1HTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |