Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006285 | 0.92 | HSD17B10 (0.39) | FAAHMEN1KMT2AHTTALOX5 | |
| SCHEMBL2003126 | 0.92 | MEN1 (0.44) | FAAHMEN1KMT2AHTTALOX5 | |
| SCHEMBL2012281 | 0.91 | FAAH (0.38) | FAAHMEN1KMT2AHTTALOX5 | |
| SCHEMBL2002956 | 0.90 | PTGES2 (0.44) | FAAHMEN1KMT2AHTTALOX5 | |
| SCHEMBL2007363 | 0.90 | ALOX5AP (0.40) | FAAHMEN1KMT2AHTTALOX5 | |
| SCHEMBL2010313 | 0.89 | FAAH (0.42) | FAAHMEN1KMT2AHTTALOX5 | |
| SCHEMBL2009855 | 0.88 | FAAH (0.43) | FAAHMEN1KMT2AHTTALOX5 | |
| SCHEMBL2005932 | 0.88 | MEN1 (0.46) | FAAHMEN1KMT2AALOX5ALOX5AP | |
| SCHEMBL2003159 | 0.88 | ALOX5AP (0.46) | MEN1KMT2AALOX5ALOX5APMAPT | |
| SCHEMBL2003496 | 0.88 | ALDH1A1 (0.40) | MEN1KMT2AKDM4EALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |