Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CALM1 | P0DP23 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30380963 | 1.00 | CYP19A1 (0.56) | CYP19A1PTGS2CALM1ALDH1A1CYP3A4 | |
| SCHEMBL15285314 | 0.89 | PTGS2 (0.57) | CYP19A1PTGS2CALM1ALDH1A1CYP3A4 | |
| SCHEMBL10474113 | 0.85 | PTGS2 (0.63) | CYP19A1PTGS2CYP3A4 | |
| SCHEMBL427550 | 0.85 | CYP19A1 (0.55) | CYP19A1PTGS2CALM1ALDH1A1CYP3A4 | |
| SCHEMBL31347520 | 0.84 | CYP19A1 (0.61) | CYP19A1TAAR1MAPK1TDP1 | |
| SCHEMBL29738341 | 0.83 | CYP19A1 (0.50) | CYP19A1PTGS2CALM1ALDH1A1CYP3A4 | |
| SCHEMBL5832074 | 0.83 | CYP19A1 (0.50) | CYP19A1PTGS2CALM1ALDH1A1CYP3A4 | |
| Butane SCHEMBL9017614 | 0.81 | CYP19A1 (0.44) | CYP19A1PTGS2CALM1ALDH1A1CYP3A4 | |
| SCHEMBL4575378 | 0.80 | CNR1 (0.38) | CYP19A1PTGS2ALDH1A1CYP3A4GABRA1 | |
| SCHEMBL10492672 | 0.80 | CNR1 (0.38) | CYP19A1PTGS2ALDH1A1CYP3A4GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339867-A1 | PYRAZINE COMPOUNDS AS INHIBITORS OF FLT3 | BIOMEA FUSION, INC. | 2023-10-26 | — | — | US | disclosed |
| WO-2023060173-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE | AQUINNAH PHARMACEUTICALS, INC. (US) | 2023-04-13 | — | — | WO | disclosed |
| US-9956213-B2 | Substituted naphthyridine and quinoline compounds as MAO inhibitors | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2018-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339867-A1 | PYRAZINE COMPOUNDS AS INHIBITORS OF FLT3 | FLT3, MCL1, CSF3R | CYP19A1 2638/4885PTGS2 3102/4885CALM1 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.