Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23888634 | 0.95 | LIPG (0.44) | KCNH2LIPGMAOAKDM1AMAOB | |
| SCHEMBL932468 | 0.87 | KDM1A (0.42) | KCNH2LIPGMAOAKDM1AMAOB | |
| SCHEMBL8241098 | 0.83 | KCNH2 (0.46) | KCNH2LIPGMAOAKDM1AMAOB | |
| SCHEMBL21706158 | 0.83 | KCNH2 (0.70) | KCNH2LIPGMAOAKDM1AMAOB | |
| SCHEMBL24261314 | 0.83 | KCNH2 (0.70) | KCNH2LIPGMAOAKDM1AMAOB | |
| SCHEMBL27916483 | 0.82 | KCNH2 (0.58) | KCNH2LIPGMAOAKDM1AMAOB | |
| SCHEMBL2567286 | 0.81 | KCNH2 (0.59) | KCNH2CYP4F2CYP4A11MAPT | |
| SCHEMBL19542 | 0.80 | KDM1A (0.44) | LIPGMAOAKDM1AMAOBTDP1 | |
| SCHEMBL15677623 | 0.78 | KCNH2 (0.47) | KCNH2LIPGMAOAKDM1AMAOB | |
| SCHEMBL29792045 | 0.77 | MPO (0.43) | KCNH2LIPGMAOAKDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3315492-B1 | PYRAZOLE DERIVATIVE, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | KISSEI PHARMACEUTICAL (JP) | 2020-09-16 | — | — | EP | disclosed |
| EP-3315492-A1 | PYRAZOLE DERIVATIVE, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2018-05-02 | — | — | EP | disclosed |