Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 8/20 | 1.00 |
| ▸ | FTO | Q9C0B1 | 8/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.59 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29493648 | 1.00 | COMT (1.00) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL30740996 | 0.92 | COMT (0.86) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL32669554 | 0.92 | FTO (0.85) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL32669757 | 0.92 | FTO (0.84) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL32669676 | 0.91 | COMT (0.82) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL32670052 | 0.91 | FTO (0.82) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL32670009 | 0.90 | COMT (0.81) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL32669539 | 0.90 | FTO (0.81) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL32669736 | 0.90 | FTO (0.81) | COMTFTOABCC3ABCC4ABCB11 | |
| SCHEMBL32670137 | 0.89 | FTO (0.80) | COMTFTOABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260035341-A1 | FTO INHIBITORS | RPXDS CO LTD (CN) | 2026-02-05 | — | — | US | claimed |
| EP-4561975-A1 | FTO INHIBITORS | RPXDS Co., Ltd (CN) | 2025-06-04 | — | — | EP | claimed |
| CN-119546566-A | FTO inhibitors | 瑞璞鑫(苏州)生物科技有限公司 | 2025-02-28 | — | — | CN | claimed |
| WO-2024022491-A1 | FTO INHIBITORS | RPXDS CO., LTD (CN) | 2024-02-01 | — | — | WO | claimed |
| US-20260035341-A1 | FTO INHIBITORS | RPXDS CO LTD (CN) | 2026-02-05 | — | — | US | disclosed |
| EP-4561975-A1 | FTO INHIBITORS | RPXDS Co., Ltd (CN) | 2025-06-04 | — | — | EP | disclosed |
| CN-119546566-A | FTO inhibitors | 瑞璞鑫(苏州)生物科技有限公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2024022491-A1 | FTO INHIBITORS | RPXDS CO., LTD (CN) | 2024-02-01 | — | — | WO | disclosed |
| US-20210238127-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-08-05 | — | — | US | disclosed |
| US-10988440-B2 | FTO inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-27 | — | — | US | disclosed |
| US-10980766-B2 | Entacapone-related compounds to treat macular degeneration | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-20 | — | — | US | disclosed |
| US-20200148628-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-05-14 | — | — | US | disclosed |
| US-20190183842-A1 | Entacapone-related Compounds to Treat Macular Degeneration | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-06-20 | — | — | US | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10980766-B2 | Entacapone-related compounds to treat macular degeneration | PDE6C, PDE6D, MC3R | COMT 469/4885FTO 2501/4885ABCC3 1471/4885 |
| US-20260035341-A1 | FTO INHIBITORS | FTO, LDLR, GPR119 | COMT 52/4885FTO 1/4885ABCC3 2378/4885 |
| US-20190183842-A1 | Entacapone-related Compounds to Treat Macular Degeneration | PDE6C, PDE6D, MC3R | COMT 469/4885FTO 2501/4885ABCC3 1471/4885 |
| US-20180118665-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885ABCC3 3114/4885 |
| US-20210238127-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885ABCC3 3114/4885 |
| US-20200148628-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885ABCC3 3114/4885 |
| US-10988440-B2 | FTO inhibitors | FTO, ALKBH3, ALKBH1 | COMT 9/4885FTO 1/4885ABCC3 3114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.