Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.48 |
| ▸ | COMT | P21964 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20100825 | 0.89 | FTO (0.61) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL24386469 | 0.78 | MAPT (0.52) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL20100841 | 0.78 | MEN1 (0.80) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL20100837 | 0.77 | FTO (0.78) | MAPTKMT2AMEN1ALDH1A1RECQL | |
| SCHEMBL20100827 | 0.77 | FTO (0.59) | MAPTKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL20100831 | 0.73 | FTO (0.62) | MAPTKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL20100833 | 0.72 | COMT (0.56) | MAPTKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL687503 | 0.70 | MAPT (0.68) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL687502 | 0.70 | MAPT (0.68) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL20100835 | 0.70 | COMT (0.78) | MAPTKMT2AMEN1ALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238127-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-08-05 | — | — | US | disclosed |
| US-10988440-B2 | FTO inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-27 | — | — | US | disclosed |
| EP-3303283-B1 | FTO INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-04-21 | — | — | EP | disclosed |
| US-10980766-B2 | Entacapone-related compounds to treat macular degeneration | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-20 | — | — | US | disclosed |
| US-20200148628-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-05-14 | — | — | US | disclosed |
| US-20190183842-A1 | Entacapone-related Compounds to Treat Macular Degeneration | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-06-20 | — | — | US | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10980766-B2 | Entacapone-related compounds to treat macular degeneration | PDE6C, PDE6D, MC3R | MAPT 1635/4885KMT2A 3759/4885MEN1 1311/4885 |
| US-20190183842-A1 | Entacapone-related Compounds to Treat Macular Degeneration | PDE6C, PDE6D, MC3R | MAPT 1635/4885KMT2A 3759/4885MEN1 1311/4885 |
| US-20180118665-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | MAPT 3510/4885KMT2A 184/4885MEN1 3683/4885 |
| US-20210238127-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | MAPT 3510/4885KMT2A 184/4885MEN1 3683/4885 |
| US-20200148628-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | MAPT 3510/4885KMT2A 184/4885MEN1 3683/4885 |
| US-10988440-B2 | FTO inhibitors | FTO, ALKBH3, ALKBH1 | MAPT 3510/4885KMT2A 184/4885MEN1 3683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.