Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.42 |
| ▸ | COMT | P21964 | 3/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20100891 | 0.89 | TDP1 (0.44) | TDP1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL20100877 | 0.87 | FTO (0.53) | TDP1ALDH1A1KMT2AMEN1FTO | |
| SCHEMBL20100878 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2ASMN1; SMN2MEN1HPGD | |
| SCHEMBL21998847 | 0.85 | FTO (0.44) | ALDH1A1KMT2AMEN1FTOCOMT | |
| SCHEMBL8471655 | 0.79 | TPMT (0.47) | ALDH1A1KMT2AMEN1HTTFTO | |
| SCHEMBL20100872 | 0.78 | FTO (0.43) | ALDH1A1KMT2ASMN1; SMN2FTOCOMT | |
| SCHEMBL29493680 | 0.78 | FTO (0.43) | ALDH1A1KMT2ASMN1; SMN2FTOCOMT | |
| SCHEMBL4608767 | 0.76 | FTO (0.68) | TDP1ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL4608763 | 0.76 | FTO (0.68) | TDP1ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL4609816 | 0.76 | FTO (0.68) | TDP1ALDH1A1KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922316-B | FTO inhibitors | 北京生命科学研究所 | 2022-04-08 | — | — | CN | disclosed |
| US-20180118665-A1 | FTO Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118665-A1 | FTO Inhibitors | FTO, ALKBH3, ALKBH1 | TDP1 1000/4885ALDH1A1 274/4885KMT2A 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.