Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 10/20 | 0.51 |
| ▸ | TUBB | P07437 | 10/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 10/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 10/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 10/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 10/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 10/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 10/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 10/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 10/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 10/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 10/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 10/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 10/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 10/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11556879 | 0.81 | HPGD (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL11656533 | 0.74 | RAB9A (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL17251712 | 0.74 | PARP1 (0.59) | BRD4TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30663468 | 0.72 | BRD4 (1.00) | BRD4TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29109165 | 0.72 | BRD4 (1.00) | BRD4TUBB4ATUBBTUBA3CTUBA1B | |
| Ethoxycarbonyl Group SCHEMBL27914664 | 0.71 | HPGD (0.44) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL8818585 | 0.71 | PARP1 (0.62) | BRD4TUBB4ATUBBTUBA3CTUBA1B | |
| Methoxy Aucuparin SCHEMBL8420787 | 0.70 | KDM4E (0.62) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL30234925 | 0.70 | TNKS (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4890491 | 0.70 | HPGD (0.56) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118693-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2018-05-03 | — | — | US | disclosed |
| US-20180118693-A1 | COMPOUNDS FOR TREATMENT OF CANCER | GTX, INC. (US) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118693-A1 | COMPOUNDS FOR TREATMENT OF CANCER | TP53, TUBB1, TUBB6 | BRD4 273/4885TUBB4A 7/4885TUBB 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.