SCHEMBL20101036

SCHEMBL20101036

Clc1ccc2sc(N/N=C(\c3ccccc3)c3ccccn3)nc2c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.76
ALDH1A1 P00352 1/20 0.76
CYP1A2 P05177 1/20 0.76
CYP3A4 P08684 1/20 0.76
HIF1A Q16665 1/20 0.76
KDM4E B2RXH2 3/20 0.56
KDM6B O15054 1/20 0.56
TET3 O43151 1/20 0.56
KDM4A O75164 1/20 0.56
KDM4B O94953 1/20 0.56
KDM5A P29375 1/20 0.56
KDM5C P41229 1/20 0.56
KDM4D Q6B0I6 1/20 0.56
TET2 Q6N021 1/20 0.56
TET1 Q8NFU7 1/20 0.56
KDM4C Q9H3R0 1/20 0.56
KDM5B Q9UGL1 1/20 0.56
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
GAA P10253 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15427107 0.86 HSP90AA1 (1.00) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL20101038 0.84 HSP90AA1 (0.71) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL20101082 0.79 HSP90AA1 (0.85) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL28720593 0.77 MAOA (0.61) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL28720595 0.77 MAOA (0.61) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL28362719 0.77 MAOA (0.58) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL28362720 0.77 MAOA (0.58) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL28720778 0.74 MAOA (0.54) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL28720784 0.74 MAOA (0.54) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A
SCHEMBL28366328 0.72 MAOA (0.72) HSP90AA1ALDH1A1CYP1A2CYP3A4HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018081612-A1 COMPOUNDS AND METHODS FOR TREATING CANCER ACTAVALON, INC. (US) 2018-05-03 WO disclosed