Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6756762 | 1.00 | PAX8 (0.57) | PAX8GAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6756763 | 1.00 | PAX8 (0.57) | PAX8GAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL20101041 | 0.82 | SMN1; SMN2 (0.74) | GAAKMT2ASMN1; SMN2MAPTHTT | |
| SCHEMBL20101022 | 0.78 | PAX8 (0.65) | PAX8GAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6715790 | 0.76 | PAX8 (0.67) | PAX8GAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL28153216 | 0.76 | KMT2A (0.75) | PAX8GAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL20101085 | 0.76 | PAX8 (0.67) | PAX8GAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL6715793 | 0.76 | PAX8 (0.67) | PAX8GAAKMT2ASMN1; SMN2MAPT | |
| SCHEMBL14540616 | 0.76 | KMT2A (0.75) | PAX8GAAKMT2ASMN1; SMN2MAPT | |
| Ferimzone SCHEMBL674026 | 0.76 | LMNA (0.56) | GAAKMT2ASMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081612-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | ACTAVALON, INC. (US) | 2018-05-03 | — | — | WO | disclosed |