Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.74 |
| ▸ | LMNA | P02545 | 7/20 | 0.74 |
| ▸ | HTT | P42858 | 6/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | KDM6B | O15054 | 1/20 | 0.53 |
| ▸ | TET3 | O43151 | 1/20 | 0.53 |
| ▸ | KDM4A | O75164 | 1/20 | 0.53 |
| ▸ | KDM4B | O94953 | 1/20 | 0.53 |
| ▸ | KDM5A | P29375 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20101040 | 0.82 | PAX8 (0.57) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL6756762 | 0.82 | PAX8 (0.57) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL6756763 | 0.82 | PAX8 (0.57) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL20101032 | 0.80 | KDM4E (0.58) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL18292348 | 0.78 | KMT2A (0.81) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL20101033 | 0.77 | KDM4E (0.58) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL4926318 | 0.77 | KDM4E (0.72) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL20101080 | 0.77 | KDM4E (0.72) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL30779129 | 0.76 | AGTR1 (0.65) | SMN1; SMN2LMNAHTTALDH1A1MEN1 | |
| SCHEMBL30779140 | 0.76 | AGTR1 (0.65) | SMN1; SMN2LMNAHTTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081612-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | ACTAVALON, INC. (US) | 2018-05-03 | — | — | WO | disclosed |