Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 6/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20102975 | 0.87 | TYK2 (0.53) | GRM1GRM5SMN1; SMN2HPGDTSHR | |
| SCHEMBL31051085 | 0.87 | SMN1; SMN2 (0.48) | GRM1SMN1; SMN2HPGDTSHRHTT | |
| SCHEMBL175236 | 0.87 | ALDH1A1 (0.49) | GRM1GRM5SMN1; SMN2HPGDTSHR | |
| SCHEMBL13087213 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDTSHRHTTLMNA | |
| SCHEMBL2786336 | 0.81 | GRM1 (0.55) | GRM1SMN1; SMN2HPGDLMNAALDH1A1 | |
| SCHEMBL2807304 | 0.78 | PDE9A (0.48) | GRM1GRM5HTTLMNAMAPT | |
| SCHEMBL30677333 | 0.78 | GRM1 (0.53) | GRM1GRM5HPGDTSHRLMNA | |
| SCHEMBL11476904 | 0.77 | RAB9A (0.63) | SMN1; SMN2HPGDHTTLMNAALDH1A1 | |
| SCHEMBL2786428 | 0.76 | RXFP1 (0.49) | GRM1SMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL20102976 | 0.75 | SMN1; SMN2 (0.54) | SMN1; SMN2HPGDTSHRHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12516052-B2 | Methyltransferase 5 (PRMT5) inhibitors and methods of treatment | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2026-01-06 | — | — | US | disclosed |
| US-20240083894-A1 | SMALL MOLECULE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) INHIBITORS AND METHODS OF TREATMENT | UNIV INDIANA TRUSTEES (US) | 2024-03-14 | — | — | US | disclosed |
| US-20230181589-A1 | PRMT5 INHIBITORS FOR OCULAR THERAPY | NATIONAL INSTITUTES OF HEALTH | 2023-06-15 | — | — | US | disclosed |
| US-11034689-B2 | Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2021-06-15 | — | — | US | disclosed |
| US-11034689-B2 | Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200062745-A1 | Small Molecule Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Methods of Treatment | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-02-27 | — | — | US | disclosed |
| US-20200062745-A1 | Small Molecule Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Methods of Treatment | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2020-02-27 | — | — | US | disclosed |
| WO-2018081451-A1 | SMALL MOLECULE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) INHIBITORS AND METHODS OF TREATMENT | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2018-05-03 | — | — | WO | disclosed |
| WO-2010118367-A2 | ANTIVIRAL PYRIMIDINES | PROGENICS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240083894-A1 | SMALL MOLECULE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) INHIBITORS AND METHODS OF TREATMENT | PRMT5, PRMT1, PRMT3 | GRM1 1285/4885GRM5 343/4885SMN1; SMN2 2595/4885 |
| US-11034689-B2 | Small molecule protein arginine methyltransferase 5 (PRMT5) inhibitors and methods of treatment | PRMT5, PRMT1, PRMT3 | GRM1 1285/4885GRM5 343/4885SMN1; SMN2 2595/4885 |
| US-20200062745-A1 | Small Molecule Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Methods of Treatment | PRMT5, PRMT1, PRMT3 | GRM1 1285/4885GRM5 343/4885SMN1; SMN2 2595/4885 |
| US-20230181589-A1 | PRMT5 INHIBITORS FOR OCULAR THERAPY | PRMT5, PRMT1, PRMT3 | GRM1 1695/4885GRM5 252/4885SMN1; SMN2 3270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.