Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103212 | 0.91 | TNKS2 (0.45) | PDE4BPDE4DTNKS2TNKSMEN1 | |
| SCHEMBL20103186 | 0.87 | PDE4B (0.45) | PDE4BPDE4DTNKS2TNKSMAPT | |
| SCHEMBL20103119 | 0.86 | PDE4B (0.44) | PDE4BPDE4DTNKS2TNKSMEN1 | |
| SCHEMBL20103478 | 0.85 | TNKS2 (0.46) | PDE4BPDE4DTNKS2TNKSMEN1 | |
| SCHEMBL20103438 | 0.84 | LMNA (0.44) | PDE4BTNKS2TNKSMEN1KMT2A | |
| SCHEMBL20103113 | 0.83 | TNKS2 (0.42) | PDE4BPDE4DTNKS2TNKSMEN1 | |
| SCHEMBL18208115 | 0.82 | PDE4B (0.44) | PDE4BPDE4D | |
| SCHEMBL18208112 | 0.82 | PDE4B (0.44) | PDE4BPDE4D | |
| SCHEMBL18208994 | 0.80 | SMN1; SMN2 (0.54) | TNKSHSD17B10 | |
| SCHEMBL18208992 | 0.80 | SMN1; SMN2 (0.54) | TNKSHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |