Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103119 | 0.92 | PDE4B (0.44) | PDE4BPDE4DTNKS2LMNAESR1 | |
| SCHEMBL20103212 | 0.89 | TNKS2 (0.45) | PDE4BPDE4DTNKS2TNKSMAPT | |
| SCHEMBL20103120 | 0.87 | PDE4B (0.46) | PDE4BPDE4DTNKS2TNKSMAPT | |
| SCHEMBL20103113 | 0.86 | TNKS2 (0.42) | PDE4BPDE4DTNKS2LMNAESR1 | |
| SCHEMBL20103438 | 0.85 | LMNA (0.44) | PDE4BTNKS2LMNAESR1TNKS | |
| SCHEMBL20103478 | 0.82 | TNKS2 (0.46) | PDE4BPDE4DTNKS2TNKSMAPT | |
| SCHEMBL20103162 | 0.81 | LMNA (0.43) | PDE4BTNKS2LMNAESR1TNKS | |
| SCHEMBL20103204 | 0.79 | PDE4B (0.44) | PDE4BPDE4DTNKS2TNKS | |
| SCHEMBL18208420 | 0.78 | KDM4E (0.52) | PDE4BPDE4DTNKSHSD17B10 | |
| SCHEMBL18208419 | 0.78 | KDM4E (0.52) | PDE4BPDE4DTNKSHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |