Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103186 | 0.92 | PDE4B (0.45) | PDE4BPDE4DTNKS2LMNAESR1 | |
| SCHEMBL20103212 | 0.92 | TNKS2 (0.45) | PDE4BPDE4DTNKS2TNKSMAPT | |
| SCHEMBL20103120 | 0.86 | PDE4B (0.46) | PDE4BPDE4DTNKS2TNKSMAPT | |
| SCHEMBL20103438 | 0.86 | LMNA (0.44) | PDE4BTNKS2LMNAESR1TNKS | |
| SCHEMBL20103113 | 0.84 | TNKS2 (0.42) | PDE4BPDE4DTNKS2LMNAESR1 | |
| SCHEMBL20103478 | 0.83 | TNKS2 (0.46) | PDE4BPDE4DTNKS2HSD11B1TNKS | |
| SCHEMBL20103162 | 0.81 | LMNA (0.43) | PDE4BTNKS2LMNAESR1TNKS | |
| SCHEMBL20103204 | 0.80 | PDE4B (0.44) | PDE4BPDE4DTNKS2TNKS | |
| SCHEMBL18208721 | 0.78 | KDM4E (0.52) | PDE4BPDE4DHSD11B1TNKSHSD17B10 | |
| SCHEMBL18208718 | 0.78 | KDM4E (0.52) | PDE4BPDE4DHSD11B1TNKSHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |