Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103368 | 0.87 | PTGDR2 (0.41) | GPR84MAPTPTGDR2FFAR4OPRL1 | |
| SCHEMBL23216460 | 0.82 | PTGDR2 (0.47) | GPR84MEN1KMT2APTGDR2 | |
| SCHEMBL12924594 | 0.80 | SIGMAR1 (0.37) | FFAR4HTR1ASIGMAR1SLC6A4 | |
| SCHEMBL11141713 | 0.74 | SLC6A4 (0.52) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL11141707 | 0.74 | SLC6A4 (0.52) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL10017476 | 0.74 | DRD2 (0.57) | MAPTSLC6A2HTR2CSLC6A3SLC6A4 | |
| SCHEMBL30888638 | 0.73 | PTGDR2 (0.45) | MEN1KMT2APTGDR2HTR2COPRM1 | |
| SCHEMBL17731175 | 0.72 | FFAR4 (0.42) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL26793826 | 0.72 | PTGDR2 (0.47) | MEN1KMT2APTGDR2 | |
| SCHEMBL28710470 | 0.72 | TAS1R3 (0.39) | MEN1KMT2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081047-A1 | CYCLOHEXYL GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |