Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103607 | 0.82 | ALOX5 (0.51) | ALOX5EPHX2ALOX5APMEN1KMT2A | |
| SCHEMBL20103613 | 0.73 | ALOX5 (0.47) | ALOX5EPHX2ALOX5APMEN1KMT2A | |
| SCHEMBL20103477 | 0.68 | EPHX2 (0.55) | ALOX5EPHX2ALOX5APMEN1KMT2A | |
| SCHEMBL20103462 | 0.66 | NPC1 (0.47) | MEN1KMT2AALDH1A1PKMTP53 | |
| SCHEMBL18711197 | 0.64 | PPARG (0.40) | MEN1KMT2ATP53MAPTGAA | |
| SCHEMBL368032 | 0.63 | CYP1A2 (0.45) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14838247 | 0.63 | CYP1A2 (0.47) | MEN1KMT2AALDH1A1TP53MAPT | |
| SCHEMBL14300652 | 0.62 | CYP1A2 (0.46) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL4065436 | 0.61 | CNR2 (0.46) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6095249 | 0.61 | MAPT (0.47) | ALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3315495-A1 | N,N' -DIARYLUREA, N,N' -DIARYLTHIOUREA AND N,N' -DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE | Universität Innsbruck (AT) | 2018-05-02 | — | — | EP | disclosed |