SCHEMBL20103477

SCHEMBL20103477

CC(C)(C)OC(=O)n1c(COc2ccc(NC(=O)Nc3ccc(Cl)c(Cl)c3)cc2)nc2ccccc21

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 8/20 0.55
ALOX5 P09917 7/20 0.55
ALOX5AP P20292 1/20 0.47
NTRK1 P04629 7/20 0.47
NTRK2 Q16620 7/20 0.47
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
ALDH1A1 P00352 1/20 0.46
PKM P14618 1/20 0.46
HTT P42858 1/20 0.45
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20103613 0.93 ALOX5 (0.47) EPHX2ALOX5ALOX5APNTRK1NTRK2
SCHEMBL20103607 0.84 ALOX5 (0.51) EPHX2ALOX5ALOX5APNTRK1NTRK2
SCHEMBL20103615 0.76 NPC1 (0.56) EPHX2ALOX5NTRK1NTRK2MEN1
SCHEMBL368032 0.72 CYP1A2 (0.45) MEN1KMT2AALDH1A1
SCHEMBL14838247 0.72 CYP1A2 (0.47) MEN1KMT2AALDH1A1
SCHEMBL20103496 0.71 ALOX5 (0.63) EPHX2ALOX5NTRK1NTRK2MEN1
SCHEMBL20103600 0.71 EPHX2 (0.63) EPHX2ALOX5ALOX5APMEN1KMT2A
SCHEMBL14300652 0.71 CYP1A2 (0.46) MEN1KMT2AALDH1A1
SCHEMBL4698252 0.71 SMN1; SMN2 (0.47) KMT2AALDH1A1PKM
SCHEMBL6095249 0.71 MAPT (0.47) ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018077898-A1 N,N'-DIARYLUREA, N,N'-DIARYLTHIOUREA AND N,N'-DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE UNIVERSITÄT INNSBRUCK (AT) 2018-05-03 WO disclosed
EP-3315495-A1 N,N' -DIARYLUREA, N,N' -DIARYLTHIOUREA AND N,N' -DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE Universität Innsbruck (AT) 2018-05-02 EP disclosed