Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 1.00 |
| ▸ | NTRK2 | Q16620 | 15/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103766 | 0.90 | NTRK1 (0.82) | NTRK1NTRK2NPC1RAB9A | |
| SCHEMBL20103543 | 0.89 | NTRK1 (0.84) | NTRK1NTRK2NPC1RAB9A | |
| SCHEMBL20103646 | 0.85 | NTRK1 (1.00) | NTRK1NTRK2NPC1RAB9A | |
| SCHEMBL20103822 | 0.85 | NTRK1 (1.00) | NTRK1NTRK2NPC1RAB9A | |
| SCHEMBL20103744 | 0.83 | NTRK1 (0.79) | NTRK1NTRK2 | |
| SCHEMBL20103644 | 0.81 | NTRK1 (0.83) | NTRK1NTRK2NPC1RAB9A | |
| SCHEMBL30933648 | 0.79 | MTOR (0.73) | NTRK1NTRK2NPC1RAB9A | |
| SCHEMBL27093076 | 0.79 | MTOR (0.73) | NTRK1NTRK2NPC1RAB9A | |
| SCHEMBL9304311 | 0.79 | NTRK1 (0.65) | NTRK1NTRK2NPC1RAB9A | |
| SCHEMBL14615295 | 0.76 | TP53 (0.64) | NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018077898-A1 | N,N'-DIARYLUREA, N,N'-DIARYLTHIOUREA AND N,N'-DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE | UNIVERSITÄT INNSBRUCK (AT) | 2018-05-03 | — | — | WO | disclosed |
| EP-3315495-A1 | N,N' -DIARYLUREA, N,N' -DIARYLTHIOUREA AND N,N' -DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE | Universität Innsbruck (AT) | 2018-05-02 | — | — | EP | disclosed |