SCHEMBL20103744

SCHEMBL20103744

O=C(Nc1ccc(F)cc1)Nc1ccc(CCc2nc3ccccc3[nH]2)cc1

nearest known ligand 0.79

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 17/20 0.79
NTRK2 Q16620 13/20 0.79
ALDH1A1 P00352 1/20 0.71
PKM P14618 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20103543 0.91 NTRK1 (0.84) NTRK1NTRK2
SCHEMBL20103766 0.88 NTRK1 (0.82) NTRK1NTRK2PKMSMN1; SMN2
SCHEMBL20103644 0.85 NTRK1 (0.83) NTRK1NTRK2ALDH1A1
SCHEMBL22425265 0.85 NTRK1 (0.62) NTRK1NTRK2ALDH1A1
SCHEMBL20103636 0.83 NTRK1 (1.00) NTRK1NTRK2
SCHEMBL20103822 0.83 NTRK1 (1.00) NTRK1NTRK2
SCHEMBL20103646 0.83 NTRK1 (1.00) NTRK1NTRK2SMN1; SMN2
SCHEMBL22425272 0.80 NTRK1 (0.64) NTRK1NTRK2ALDH1A1
SCHEMBL30933853 0.80 MTOR (0.74) ALDH1A1PKMSMN1; SMN2
SCHEMBL24430191 0.80 NTRK1 (0.56) NTRK1NTRK2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018077898-A1 N,N'-DIARYLUREA, N,N'-DIARYLTHIOUREA AND N,N'-DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE UNIVERSITÄT INNSBRUCK (AT) 2018-05-03 WO disclosed
EP-3315495-A1 N,N' -DIARYLUREA, N,N' -DIARYLTHIOUREA AND N,N' -DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE Universität Innsbruck (AT) 2018-05-02 EP disclosed