Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30472331 | 0.73 | NR4A2 (0.48) | LMNAGRM6ALDH1A1RAB9AHTT | |
| SCHEMBL29031850 | 0.73 | NR4A2 (0.48) | LMNAGRM6ALDH1A1RAB9AHTT | |
| SCHEMBL28768946 | 0.70 | IGF1R (0.39) | ALDH1A1NPSR1POLBMAPTHPGD | |
| SCHEMBL2012056 | 0.68 | LMNA (0.50) | LMNAALDH1A1RAB9ASMN1; SMN2PDE4A | |
| SCHEMBL15579812 | 0.68 | AR (0.36) | GRM6NPSR1GABRA1GABRG2GABRB3 | |
| SCHEMBL2431068 | 0.68 | AR (0.36) | GRM6ALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL28046061 | 0.67 | FABP4 (0.35) | LMNAGRM6ALDH1A1RAB9ANPSR1 | |
| SCHEMBL12293219 | 0.67 | AR (0.34) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL15174105 | 0.66 | NR4A2 (0.69) | LMNAALDH1A1RAB9AHTTNPSR1 | |
| SCHEMBL27987654 | 0.66 | GRM6 (0.45) | LMNAGRM6ALDH1A1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513061-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. Lundbeck A/S (DK) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011072691-A1 | PYRIDONE DERIVATIVES AS NK3 ANTAGONISTS | H. LUNDBECK A/S (DK) | 2011-06-23 | — | — | WO | disclosed |