Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.64 |
| ▸ | MEN1 | O00255 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | GAA | P10253 | 6/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | BRD2 | P25440 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22111515 | 0.88 | KDM4E (0.78) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL15922546 | 0.84 | KMT2A (0.56) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL6093649 | 0.75 | KDM4E (0.80) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL7673685 | 0.73 | MEN1 (0.56) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL18834071 | 0.73 | KMT2A (0.44) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL16028787 | 0.71 | ALDH1A1 (0.43) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL7090585 | 0.71 | KDM4E (0.54) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL15923883 | 0.68 | GAA (0.51) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL8350979 | 0.68 | MEN1 (0.44) | KDM4EMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL9300858 | 0.67 | KDM4E (0.72) | KDM4EMEN1KMT2AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-B1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-02 | — | — | EP | disclosed |