Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 3/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25924039 | 0.82 | ALDH1A1 (0.35) | ALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL25924049 | 0.81 | CHRM5 (0.44) | ALDH1A1FAAHSIGMAR1KDM1ASMN1; SMN2 | |
| SCHEMBL25924065 | 0.80 | KDM1A (0.30) | KDM1A | |
| SCHEMBL21349220 | 0.80 | HTT (0.42) | ALDH1A1L3MBTL1SIGMAR1THRBATM | |
| SCHEMBL21088369 | 0.78 | POLB (0.38) | KDM1A | |
| SCHEMBL25923913 | 0.76 | KDM1A (0.33) | KDM1A | |
| SCHEMBL25923869 | 0.73 | NPSR1 (0.33) | KDM1AHTT | |
| SCHEMBL21088950 | 0.72 | DRD2 (0.31) | KDM1A | |
| SCHEMBL20106998 | 0.71 | AR (0.30) | — | |
| SCHEMBL21088777 | 0.71 | KDM1A (0.40) | ALDH1A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532459-B1 | LSD1 INHIBITORS AND MEDICAL USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2018081343-A1 | LSD1 INHIBITORS AND MEDICAL USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |